Letloa Trust supports indigenous San communities in northwest and western Botswana with sustainable development through community-based natural resource management (CBRM), land and cultural resource mapping, and combatting the impacts of climate change.
It works in the indigenous natural products sector to develop economic opportunities, collaborating with Biotrade Ventures to add value to plant species with commercial potential.

The trust also provides community health services with HIV and TB programmes (see activities).

Its mission is to develop a network of professional organizations and programmes with competent and responsible San leadership.

The Letloa Trust vision is for San people to have permanent control over their lives, resources and destiny.